The present experiment was designed to make a systematic study of experimentally induced immunotoxicity of lead acetate and its amelioration with Ocimum sanctum (OS) in male wistar rats. In the present investigation rats were randomly divided into six groups (n=36). Rats of group II and III were treated with different doses of lead acetate @ 60 mgs and 30 mgs / Kg.b.wt. / 3days a week respectively and to study immunomodulatory effect Ocimum sanctum given orally @ 400mg/Kg b.wt. for other IV and V groups of rats along with lead acetate over a period of 12 weeks. Group I and VI served as DW and OS control. Significant reduction in the both HA titer and DNCB contact sensitivity score was observed in the lead acetate treated groups and depletion of lymphocytes in spleen, lymphnodes and thymus indicates lead acetate has immunotoxic effect. Where as significant improvement in the immunity was noticed in the Ocimum sanctum treated groups indicates immunomodulatory property.
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